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KMID : 0984720040360060377
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Infection and Chemotherapy
2004 Volume.36 No. 6 p.377 ~ p.380
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A Case of Systemic Vasculitis Presented as Fever of Unknown Origin.
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Jung Eun-Suk
Kim Chung-Ho
Hyun Young-Youl
Ko Gang-Jee
Hwang Byoung-Yun
Cheong Hee-Jin
Kim Woo-Joo
Won Nam-Hee
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Abstract
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Fever of unknown origin (FUO) means fever that does not resolve spontaneously in the period expected for self-limited infection and whose cause cannot be ascertained despite considerable diagnostic efforts. We experienced a case of FUO associated with systemic vasculitis, which was diagnosed with clinical manifestation, radiographic findings, the presence of anti-neutrophil cytoplasmic antibody (ANCA), and renal biopsy. A 54-year-old female was admitted to our hospital with remittent fever of 3 months. A paranasal sinus (PNS) view revealed maxillary and ethmoidal sinusitis, and urine analysis showed microscopic hematuria. We performed a renal biopsy on the basis of positive ANCA and microscopic hematuria. The renal biopsy showed pauci-immune crescentic glomerulonephritis without granuloma, interstitial inflammation, and small vessel vasculitis. Under the diagnosis of ANCA-associated systemic vasculitis, she was treated with steroid and cyclophosphamide. She showed marked clinical improvement.
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KEYWORD
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Fever of unknown origin (FUO), Systemic vasulitis, ANCA
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